Structure of hypothetical Mo-cofactor biosynthesis protein B (ST2315) fromSulfolobus tokodaii
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چکیده
منابع مشابه
Crystal structure of the molybdenum cofactor biosynthesis protein MobA from Escherichia coli at near-atomic resolution.
BACKGROUND All mononuclear molybdoenzymes bind molybdenum in a complex with an organic cofactor termed molybdopterin (MPT). In many bacteria, including Escherichia coli, molybdopterin can be further modified by attachment of a GMP group to the terminal phosphate of molybdopterin to form molybdopterin guanine dinucleotide (MGD). This modification reaction is required for the functioning of many ...
متن کاملTHE DUAL ROLE OF THE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN MOCS3 IN tRNA THIOLATION AND MOLYBDENUM COFACTOR BIOSYNTHESIS IN HUMANS
Background: E1-like proteins are required for activation and thiocarboxylation of β-grasp fold proteins involved in sulfurtransfer to cofactors and tRNA. Results: MOCS3 interacts with both URM1 and MOCS2A in vivo and in vitro. Conclusion: Molybdenum cofactor biosynthesis and tRNA thiolation steps are linked by the MOCS3 protein in humans. Significance: To understand the mechanism of protein con...
متن کاملDual role of the molybdenum cofactor biosynthesis protein MOCS3 in tRNA thiolation and molybdenum cofactor biosynthesis in humans.
We studied two pathways that involve the transfer of persulfide sulfur in humans, molybdenum cofactor biosynthesis and tRNA thiolation. Investigations using human cells showed that the two-domain protein MOCS3 is shared between both pathways. MOCS3 has an N-terminal adenylation domain and a C-terminal rhodanese-like domain. We showed that MOCS3 activates both MOCS2A and URM1 by adenylation and ...
متن کاملAntimetabolite poisoning of cofactor biosynthesis.
The lack of new antibiotics coupled with the increased prevalence of multidrugresistant bacterial pathogens is cause for great concern (Wright, 2012). The genomics revolution predicted a new era in antibiotics discovery with the delivery of an abundance of conserved and essential targets (Payne et al., 2007). However, target-based approaches for antibacterial discovery have proven quite challen...
متن کاملMolybdenum Cofactor Biosynthesis in Humans
Molybdenum cofactor deficiency is a devastating disease with affected patients displaying the symptoms of a combined deficiency of sulfite oxidase and xanthine dehydrogenase. Because of the extreme lability of the isolated, functional molybdenum cofactor, direct cofactor replacement therapy is not feasible, and a search for stable biosynthetic intermediates was undertaken. From studies of cocul...
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ژورنال
عنوان ژورنال: Acta Crystallographica Section F Structural Biology and Crystallization Communications
سال: 2009
ISSN: 1744-3091
DOI: 10.1107/s1744309109043772